- Apoptotic Pathway Induced by Dominant Negative ATM Gene in CT-26 Colon Cancer Cells
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Jung Chang Lee, Ho Keun Yi, Sun Young Kim, Dae Yeol Lee, Pyoung Han Hwang, Jin Woo Park
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Clin Exp Pediatr. 2003;46(7):679-686. Published online July 15, 2003
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Purpose : Ataxia telangiectasia mutated(ATM) is involved in DNA damage responses at different cell cycle checkpoints, and signalling pathways associated with regulation of apoptosis in response to ionizing radiation(IR). However, the signaling pathway that underlies IR-induced apoptosis in ATM cells has remained unknown. The purpose of this study was, therefore, to investigate the apoptotic pathway that underlies IR-induced apoptosis in... |
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- Novel Gap Junction Molecules, Connexin 37, Enhances the Bystander Effect in HSVtk/GCV Gene Therapy
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Sun Young Kim, Ho Keun Yi, Jung Chang Lee, Dong Jin Hwang, Pyoung Han Hwang, Dae Yeol Lee, Soo Chul Cho
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Clin Exp Pediatr. 2003;46(6):541-547. Published online June 15, 2003
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Purpose : Gap junction intercellular communication(GJIC) is an important mechanism of the bystander effect in herpes simplex thymidine kinase/ganciclovir(HSVtk/GCV) gene therapy Therefore, we attempted to enhance the bystander effect in vitro by exogenous overexpressing connexin 37(Cx37) in cells to increase GJIC.
Methods : NIH3T3 cells were transfected with the Cx37 and HSVtk gene or the HSVtk gene alone by the calcium... |
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